EFTA00586622.pdf

August 30, 2015 Mr. Jeffrey Epstein The Jeffrey Epstein VI Foundation St. Thomas, The U.S. Virgin Islands Dear Jeffrey: I am honored by your interest in my work at Chi Wellness Clinic. Your friend, Gina Offenstine came to see me ten years ago for her pains. Recently she brought her husband, Herb and son, Adam for treatments. I am deeply impressed when Gina mentioned your amazing achievements in investment and philanthropy. I admire and appreciate especially your vision in supporting cutting edge scientific research and education. On the morning of September 11, 2001, I started up the holistic healthcare clinic in Longwood Medical Areas. It currently provides services in Boston, Somerville and Waltham in MA. Gina mentions you are coming to Boston in ten days. I appreciate if you let me to take you to an exciting dinner and walk around cool area in Boston. As Chi Wellness enters its 151h year, I look for my first long-term partner to create a school for training blind and sighted students together to diagnose and treat various tension-driven health conditions based on my tensiology research and development; expand clinical services to other regions of the United States; and create a research institute for clinical evaluation of safety and efficacy of holistic care therapies. I grew up in Xiamen, Fujian Province in China. Historically known as Amoy, Xiamen was the world's premier tea port where four ships sailed to Boston in 1773, which led to the Boston Tea Party and the American Independence Revolution. In childhood, I had apprenticed in herbal medicine and carpentry. After graduating from high school at 16, I was a rice farmer for 4 years in a primitive village in Nanping, a major tea producing region of Mount Wuyi in China. In 1982, I graduated from Xiamen University with a BS degree in oceanography and published my first research paper with the discovery of color vision in a marine shrimp. I came to the US in 1983 and attended the University of Rhode Island Graduate School of Oceanography in Narragansett for a MS in marine ecosystems. I decided to switch my study from oceanography to neuroscience at Marine Biological Laboratory in Woods Hole. I went on to California Institute of Technology in Pasadena for a MS in computation & neural systems in 1987, and later to University of Southern California for a PhD in neurobiology of learning and memory in 1993. Before I founded Chi Wellness, I was a neuroscientist at Massachusetts Institute of Technology, Cambridge. My research focus was in the mechanisms of learning, memory and awareness in the mammalian brain. I studied deficits in synaptic plasticity and leaming/memory behaviors in various gene-knockout mice. My research results had been published in Science, Cell, Neuron, and Annual Reviews of Neuroscience. I had presented my tensiology findings in a medical symposium on degenerative diseases in Boston. Please see the attachment for my CV for more information. All the best, "Miles" Chong Chen Email (SMS for US or WhatsApp for international) Website: www.chiwellness.com EFTA00586622 EFTA00586623 "Miles" Chong Chen, PhD EDUCATION 1982. B.S. in Marine Biology. Xiamen University, Xiamen, Fujian, China. 1985. M.S. in Biological Oceanography. University of Rhode Island, Naragansett, RI, USA. 1987. M.S. in Marine Biology (Boston University). Marine Biological Laboratory, Woods Hole, MA, USA. 1990. M.S. in Computation & Neural Systems, an interdisciplinary program to investigate complex problems in the brain. California Institute of Technology, Pasadena, CA, USA. 1993. Ph.D. in Neurobiology, an interdisciplinary program to study mechanisms of learning and memory in the brain. University of Southern California, Los Angeles, CA, USA. EXPERIENCE Marine Biology Research 1981-1982. Undergraduate Researcher. Xiamen University, Xiamen, China. Studied color vision of compound eyes in marine shrimp using extracellular recording technique. 1983-1985. Graduate Researcher. Marine Ecosystems Research Laboratory (MERL), Narragansett, RI. Studied the effect of hydrogen sulfide on the metabolism of coastal bivalves, Solmnya velum and enzymes of sulfide oxidation in gill tissue. 1985-1987. Graduate Researcher. Marine Biological Laboratory, Woods Hole, MA. Studied biophysical changes in neuronal excitability in photoreceptor underlying learning and memory in sea slug, Hermissenda crassicornis using intracellular recording. Neuroscience Research 1987-1990. Graduate Researcher. Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA. Modeled and simulated biological vision, learning and memory through computer neural network (software) and analog VLSI silicon chip (Vary Large Scale Integration Circuit). 1990-1993. Doctorate Researcher. University of Southern California, Los Angeles, CA. Studied synaptic plasticity using extracelluar recording technique underlying associative learning of conditioned eyeblink response in rabbits. 1992-1993. Post-Doctorate Fellow. Salk Institute for Biological Studies, La Jolla, CA. Studied synaptic plasticity using patch clamp technique. 1993-1998. Research Scientist. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA. Studied the molecular, physiological and behavioral deficiencies in gene-knockout mouse models of psychiatric and motor dysfunctions. Studied genetic. molecular cellular and behavioral mechanisms underlying learning & memory in mice. EFTA00586624 Holistic Health Care 2001—Present. Founder/Director, Chi Wellness Clinic, Boston, MA. Research, development and administration in providing holistic healthcare and wellness to patients with chronic conditions. Currently three offices in Boston, Somerville and Waltham, MA. 2005-2006. Research Fellow, Center for Interventional Radiology (Elvira Lang, MD), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Research and development of complementary therapies as an alternative to pharmacologic agents in relief of pain and anxiety during minimally invasive procedures. 2006-2007. Adjunct Professor, Massachusetts College of Pharmacy and Health Sciences, Boston, MA. Lectures in holistic health care, and mind and body medicine. 2007-2012. Co-Founder/Co-Director, Chi NeuroHealth Clinic, Manchester, NH. Providing both holistic care and conventional neurological services (Ken Logan, MD) to patients with neurodegenerative diseases including MS, Parkinson's. Other Experience 1973-1975. Apprentice Herbalist. Nanping Medical and Pharmacy Company, Nanping, China. Learned traditional methods of processing and formulation of Chinese Herbs. 1975-1978. Farmer. Kengjia Village, Xiqin Commune, Nanping, Fujian, China. Engaged in traditional farming of rice, vegetables, peanut and sweet potatoes. 1999-2004. Filmmaker. Produced and directed the documentary film, Healing Touch of the Blind about 30,000 blind massage therapists who enjoy respect for their gifted tactile sense and 90% employment rate in China. 20 minutes length. In DVD format. SYMPOSIUMS 1995. The 28th Annual Winter Conference on Brain Research, January 22, 1995. Steamboat Springs, Colorado. Workshop: Electrophysiological Role of 5-HT in Behavior: In vitro Analysis of Behavioral Effects. 1995. The 12th British Brain Research Association Annual Meeting, March 31, 1995. Oxford, United Kingdom. Plenary Lecture: Gene Knockout Mice for the Analysis of Learning and Memory Mechanisms. 1995. The 3rd Symposium on Long-term Potentiation: A Debate of Current Issues. May II, 1995. Carry-le-Rouet, France. Lecture: Mechanisms of Synaptic Plasticity and Memory in the Mammalian Brain: the Gene Knockout Approach. 1996. The 19th International Symposium on Brain Sciences of the Taniguchi Foundation, March 14- 17, 1996. Nam, Japan. Lecture: Gene Targeting and New Development in Neurobiology. EFTA00586625 2008. Chen, C. Zhang, Y. & Logan, K. BioSymposium on Sporadic Neurodegeneration : Genes, Environment and Therapeutic Strategies. May 13, 2008. Poster presentation: Tuina Therapy as Novel Therapeutic Strategy for Neurodegenerative Diseases. Organized by Robert Brown, MD, professor of neurology, and director of Day Neuromuscular Research Laboratory, Massachusetts General Hospital. Boston, MA. PUBLICATIONS First Author Chen, C. et al. 1982. A preliminary study of color vision of Penaeirs. Oceanography of Taiwan Strait 1(2): 106-109. Chen, C., B. Rabourdin, and C. Hammen. 1987. The effect of hydrogen sulfide on the metabolism of Solemya velum and enzymes of sulfide oxidation in gill tissue. Comp. Biochem. Physiol. 88B:949-952. Chen, C., et al. 1993. Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus: regulation by extracellular calcium. Hippocampus 3 (2), 193-203. Chen, C., et al. 1994. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-CaM kinase II. Science 266, 291-294. Chen, C (1995). Wagnerian genetics. Response to H Vogel's comment on our article (Chen et al, 1994. Science 266: 291-294). Vogel compared our aggressive mutant mouse to Siegfried, a character in Wagner's opera Ring Cycle). Science 27 Jan 1995: 437. Chen, C (1995). Lights, Camera ... and Action! My proposal of specifying each author's contribution in research publication as done in movie business. Science 6 Oct 1995: 14. Chen, C. et al. 1995. Temporal specificity of long-term depression in parallel fiber-Purkinje synapses in rat cerebellar slice. Learning & Memory 2, 185-198. Chen, C. et al. 1995. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC-gamma mutant mice. Cell 83, 1233-1242. Chen, C. et al. 1995. Biochemical underpinnings of behavioral abnormalities in mice. J. NIH Research 7, 50-51. Chen, C. et al. 1995. Analysis of synaptic plasticity and memory in the mammalian brain by gene knockout approach. In (M. Baudry and J. L. Davis, ed.) Long-term Potentiation: A Debate of Issues, Part 3. MIT Press, Cambridge, MA. Chen, C. and S. Tonegawa (1996). Molecular genetic analysis of synaptic plasticity, activity- dependent neural development, learning, and memory in the mammalian brain. Annu. Review Neurosci. 20, 157-184. Chen, C. et al. 1996. Hippocampal lesion impairs contextual fear conditioning in two strains of EFTA00586626 mice. Behay. Neurosci. 110(5): 1177-80. Co-Author Abeliovich, A., et al. 1994. Modified hippocampal long-term potentiation in PKCgamma-mutant mice. Cell 75, 1253-1262. Li, Y., et al. 1994. Whisker-related neuronal patterns fail to develop in the trigeminal brainstem nuclei of NMDAR1 knockout mice. Cell 76, 427-437. Aiba, A., et al. 1994. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluRI mutant mice. Cell 79, 365-375. Aiba, A., et al. 1994. Deficient cerebellar long-term depression and impaired motor learning in mGluRI mutant mice. Cell 79, 377-388. Kano, M., et al. 1995. Impaired synapse elimination during cerebellar development in PKCgamma mutant mice. Cell 83, 1223-1231. Malmberg, AB, et al (1997). Preserved Acute Pain and Reduced Neuropathic Pain in Mice Lacking PKCy. Science 10 October 1997: 279-283. Shibuki, K. et al. 1996. Deficient cerebellar long-term depression, impaired eyeblink conditioning and normal motor coordination in GFAP mutant mice. Neuron 16, 587-599. EFTA00586627