EFTA00671056.pdf

From: Faculty of 1000 To: Jeff Epstein <jeeproject@yahoo.corn> Subject: February update: Cells on standby - down but not out Date: Tue, 08 Feb 2011 17:11:48 +0000 If you're having trouble viewing this message, click to view in your default browser. ur Advert ;',F1000 Monthly Update Evaluations Rankings Reports Posters Magazine Faculty February 2011 ;N:low Editor's n Choice : "dow [; 1clow Top [;,;dow E.;.dow i—Features --I— Reports- Posters n 7 Editor's Choice Microbiology: The Great Escape How a virus escapes from membrane vacuoles to infect other cells. Physiology: Time and Temperature Body temperature resets circadian rhythms. Down but Not Out Cells on standby are surprisingly busy. Hilary Colter thinks they might be busy protecting themselves against oxidative damage. Art F1000 Hidden Jewel. Developmental Biology: Losers Fight Back How cells escape death after a temporary setback. F1000 Features ;‘, top Impure Genius Lewis Cantley has made a career of turning chemical contaminants into groundbreaking discoveries - including novel lipids, potent inhibitors, and kinases involved in cancer. Karen Hopkin Glacebo;41link;41twit;41youtu ok link ed-in ter be link link link New this Month 1,209 Evaluations added 5 Articles that Change Clinical Practice 14 Articles with an F1000 Factor of 11+ Current Issue ; 41atest issue Face to Face with the Emotional Brain How the amygdala responds to facial signals predicts both normal and psychopathologic emotional states. Ahmad R. Hariri & Paul J. Whalen The Genes of Parkinson's Disease The minority of Parkinson's cases now known to have genetic origins are shedding light on the cellular EFTA00671056 When Stress Is Good Fast blood flow protects against atherosclerosis: implications for treatment. Christina M. Warboys, Narges Amini, Amalia de Luca. and Paul C. Evans One on One: Parasites Unite! Gabriele Sorci discusses how invaders can band together to more effectively infect hosts. Do Fruit Flies Dream of Electric Bananas? Visualizing neuronal activity in small brains over four dimensions. Bfitim Brembs ;t2, Top 7 Evaluated Articles t-)12 1 Immune response feeds parasite Salmonella is able to outcompete resident gut microbes by deriving energy from the inflammatory immune response that is supposed to combat the pathogen. 2 Lung disease drug kind to muscles Patients with acute respiratory distress syndrome using a neuromuscular blocker are more likely than those on a placebo to survive 90 days, and show no increase in muscle weakness-a common concern among doctors. 3 Making peace with gut flora Dendritic cells in the gut have beta-catenin signaling turned on constantly in order to subdue inflammation and keep immune cells tolerant to commensal bacteria and food antigens, offering a potential therapeutic target for autoimmune diseases. 4 Thermo dynamics Plants and yeast may be able to sense temperature through histone-mediated nucleosome rearrangements, which result in variations in gene expression, posing a possible mechanism for response to temperature stress. 5 New function for noncoding RNAs Long noncoding RNAs, previously known to silence expression of certain genes. also play a role in gene activation. 6 Antibody action Previously assumed to only act extracellularly, researchers show that antibodies can fight viruses inside the cell as well. 7 Pain relief for the addicted In opiate-dependent patients, pain relief is tough to achieve, but those who received an N-methyl-d-aspartate receptor antagonist with anesthesia during back surgery reported less pain and needed less morphine during recovery. This F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period in the previous month. described by The Scientist reporting team. See also Top 7s in Medicine, Neuroscience, Immunology. To see the latest rankings. visit http://11000.com. Reports i tiP The latest peer-reviewed F1000 Reports articles, published in F1000's two PubMed-indexed journals, are now available to view. mechanisms of all the rest. Bobby Thomas and M. Flint Beal Opening a Can of Worms A father's determination to help his son resulted in an experimental treatment for autism that uses roundworms to modulate inflammatory immune responses. Bob Grant Naturally Selected Sir lain Chalmers rips into clinical researchers for not understanding what is know, not stating clearly what their research adds, and not publishing negative or 'disappointing' results. Recommend a Free 30-day Trial to your Librarian You can use our online form to send your recommendation. Alternatively. you may qualify for free access via HINARI or Faculty Member sponsorship. EFTA00671057 Chemical signaling in the gastrointestinal tract L. Caetano M. Antunes, Julian E. Davies and B. Brett Finlay Screening for pancreatic cancer: what can cyst fluid analysis tell us? Walter G. Park The coming health crisis: indirect health effects of global climate change Samuel S. Myers and Aaron Bernstein Is deep brain stimulation a prospective "cure" for addiction? Wayne Hall and Adrian Carter F1000 Posters Evaluated Poster of the Month ; b.,evaluated poster Neuroscience Bilateral lesions of the subthalamic nucleus prevent escalation of cocaine intake in rats Cohen et al. Based on: Neuroscience 2010 meeting. Evaluated by Trevor W Robbins, University of Cambridge. UK Summary I Poster I Evaluation View our latest submissions, including from the recent: • Neuroscience 2010 meeting • 5th Conference of the Hellenic Society for Computational Biology and Bioinformafics • 52nd American Society of Hematology (ASH) Annual Meeting and Exposition r'-2 posit a poster You have received this message because you asked to receive updates from Faculty of 1000. For further information or enquiries please contact Customer Services at info@f1000.com. Your registered email address is: jeeproject@yahoo.com. If you do not wish to receive any further messages, you may click here to unsubscribe at any time. F1000, Faculty of 1000 Ltd I Science Navigation Group I Registered in England and Wales with Company Number 3739756. Middlesex House, 34.42 Cleveland Street I London, WIT 4LB I United Kingdom EFTA00671058