EFTA00682356.pdf

From: Faculty of 1000 < To: Jeff Epstein <jeeproject@yahoo.com> Subject: F1000 March 2011 update: Mitotic Hijacker Date: Thu, 10 Mar 2011 16:37:49 +0000 If you're having trouble viewing this message, click to view in your default browser. ££1000 Monthly Update Evaluations Rankings Reports Posters Magazine Faculty March 2011 ;`‘clow Editors n Choice Editor's Choice dow Fcatures;: Top L;dow ir 7 Reports2I-dow Posters Immunology: Come Inside Antibodies can block disease spread from inside a cell. Drug Discovery: Bitter Pill Bitter-tasting molecules relax bronchial muscles. Mitotic Hijacker How a parasite sneakily ensures its own replication. Physiology: Calcium Kicks Calcium channel regulation in fight-or-flight response. F1000 Features to2 facebo;:,' link gjtwi gjyoutu ok link ed-in ter be link link link New this Month 1,204 Evaluations added 7 Articles that Change Clinical Practice 14 Articles with an F1000 Factor of 11+ Current Issue latest issue Infographic: Epigenetics -A Primer Epigenetic effects regulate the activation or repression of genes in many ways. Here are a few of the molecular tricks, illustrated. Stefan Kubicek EFTA00682356 Gr One on One: Imprinting Diversity Joachim Messing talks about how genomic imprinting may be a strong driver of diversity. Cristina Luiggi Epigenetics and Society Did Erasmus Darwin foreshadow the tweaking of his grandson's paradigm? Andrew D. Ellington Ready, Reset, Go Rudolf Jaenisch enjoys climbing mountains. rafting rapids, and unraveling the secrets of pluripotency -- knowledge that could someday lead to personalized regenerative medicine. Karen Hopkin The Footprints of Winter Epigenetic marks laid down during the cold months of the year allow flowering in spring and summer. Ralf M011er and Justin Goodrich Top 7 Evaluated Articles top A snapshot of the highest-ranked articles from a 30-day period. 1 Drug helps, doesn't hurt, lung disease Respiratory distress syndrome patients treated with a neuromuscular blocker are more likely than those on a placebo to survive 90 days. and show no increase in muscle weakness - a common concern among doctors. 2 Skip the surgery? A nonsurgical treatment for severe aortic stenosis. a type of heart disease characterized by the narrowing of the aortic valve opening, may provide an alternative for patients who are not candidates for open-heart surgery. The treatment replaces the aortic valve through a catheter. 3 How T regs limit inflammation T regulatory cells can multiply their numbers by secreting the cytokine interleukin IL-35, which converts the population of killer T cells into regulatory cells that suppress inflammation, providing a new explanation for how inflammation is reeled in after an infection is cleared. 4 Natural helpers fight infection A novel population of innate immune cells, identified in the gut adipose tissue of humans and mice and nicknamed "natural helper cells." produce large amounts of cytokines and may play an important role in fighting off parasites. 5 Cells sticking together In response to tension from adjacent cells, alpha-catenin, a cell adhesion protein, recruits actin binding proteins to strengthen cell-to-cell junctions, rapidly reacting to rearrangements in the local environment. 6 Silent effects Mutations in exons that do not change protein sequences can still have dramatic effects on gene expression in E. coli. Surprisingly, these effects are caused by Epigenetic Changes in Cancer The study of how covalent marks on DNA and histones are involved in the origin and spread of cancer cells is also leading to new therapeutic strategies. Mane! Esteller Environmental Impact Research in behavioral epigenetics is seeking evidence that links experience to biochemistry to gene expression and back out again. David Berreby Best Places to Work for Postdocs, 2011 Setting up your own scientific laboratory is no easy task, but this year's respondents are using their postdoc experiences to prepare for the challenge. Cristina Luiggi Naturally Selected Desmond Julian. who invented the concept of the coronary care unit, talks about the importance of charity- funded research, prevention of heart disease, and the British Heart Foundation's 'Mending Broken Hearts' campaign. Recommend a Free 30-day Trial to your Librarian You can use our online form to send your recommendation. Alternatively. you may qualify for free access via HINARI or Faculty Member sponsorship. EFTA00682357 changes in mRNA stability, not by codon bias. 7 Rat dad's diet affects pups Male rats fed a high-fat diet had daughters with diabetes-like beta-cell dysfuncfion, showing, for the first time in mammals, that environment of the father can influence the phenotype of the offspring. This F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period in the previous month, described by The Scientist reporting team. See also Top 7s in Molecular Biology, Genetics and Genomics, Biochemistry and Cell Biology To see the latest rankings. visit Reports top The latest peer-reviewed F1000 Reports articles, published in F1000's two PubMed- indexed journals, are now available to view. Medulloblastoma: Laminar fate advances and specification in the challenges cerebral cortex Martine F. Roussel and Nicolas Gaspard and Giles Robinson Pierre Vanderhaeghen The role of blood flow Clostridium difficile-a in determining the moving target sites of atherosclerotic Glenn S. Tillotson and plaques Joni Tillotson Narges Amini, Amalia de Luca. Christina M. Warboys and Paul C. Evans F1000 Posters Evaluated Poster of the Month Neuroscience Gy Role of dopamine and serotonin receptors in medial prefrontal and orbitofrontal cortex on impulsive choice in rats Gipson et al. Based on: Neuroscience 2010 meeting. Evaluated by Trevor W Robbins, University of Cambridge, UK Summary I Poster I Evaluation top Recent conferences covered include: • 23rd Lorne Cancer Conference 2011 • Biochemical Society 2011 - Recent Advances in Membrane Biochemistry • Biochemical Society 2011 - Stress Responses - Molecules, Organisms and Environment ;t' EFTA00682358 You have received this message becauseyou asked to receive updates from Faculty of 1000. For further information or enquiries please contact Customer Services at . Your registered email address is: If you do not wish to receive any further messages, you may click here to unsubscribe at any time. F1000, Faculty of 1000 Ltd I Science Navigation Group I Registered in England and Wales with Company Number 3739756. Middlesex House, 34.42 Cleveland Street I London, WIT 4L8 I United Kingdom EFTA00682359