EFTA02330378.pdf

From: Karyna Shuliak Sent: Tuesday, December 29, 2015 4:43 AM To: Jeffrey Subject: Low-frequency vibratory exercise reduces the risk of bone fracture more than walking: a randomized controlled trial http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693558/ • NCBI <http://www.ncbi.nlm.nih.gov/> • Skip to main content • Skip to navigation • Resources • How To • About NCBI =ccesskeys Sign =n to NCBI PMC US National Library of =edicine <http://www.nlm.nih.gov/> National Institutes of =ealth chttp://www.nih.govi> Search databasePMCAll DatabasesAssemblyBioProjectBioSampleBioSystemsBooksClinVarCloneConserved DomainsdbGaPdbVarEpigenomicsESTGeneGenomeGEO DataSetsGEO =rofilesGSSGTRHomoloGeneMedGenMeSHNCBI Web SiteNLM =atalogNucleotideOMIMPMCPopSetProbeProteinProtein ClustersPubChem =ioAssayPubChem CompoundPubChem =ubstancePubMedPubMed HealthSNPSRAStructureTaxonomyToolKitToolKitAllToolKitBookUniGene Search =erm Search Limits <http://www.ncbi.nlm.nih.gov/pmc/limits/> Advanced Journal list Help Journal List BMC Musculoskelet Disord v.7; 2006 <http://www.ncbi.nlm.nih.gov/pmc/issues/126480/> PMC1693558 BMC =usculoskelet Disord. 2006; 7: 92. Published online 2006 Nov =0. doi: 10.1186/1471-2474-7-92 PMCID: PMC1693558 <=div> EFTA_R1_01261995 EFTA02330378 Low-frequency =ibratory exercise reduces the risk of bone fracture more than walking: = randomized controlled trial Narcis =usi,1 Armando =aimundo,2 and Alejo Leal3 Author information ► Article notes ► Copyright and License information ► This article has been cited by other =rticles in PMC. Go =o: Abstract Background Whole-body vibration (WBV) is a new type of exercise =hat has been increasingly tested for the ability to prevent bone =ractures and osteoporosis in frail people. There are two currently =arketed vibrating plates: a) the whole plate oscillates up and down; b) =eciprocating vertical displacements on the left and right side of a =ulcrum, increasing the lateral accelerations. A few studies have shown =ecently the effectiveness of the up-and-down plate for increasing Bone =ineral Density (BMD) and balance; but the effectiveness of the =eciprocating plate technique remains mainly unknown. The aim was to =ompare the effects of WBV using a reciprocating platform at frequencies =ower than 20 Hz and a walking-based exercise programme on BMD and =alance in post-menopausal women. Methods Twenty-eight physically untrained post-menopausal women were =ssigned at random to a WBV group or a Walking group. Both experimental =rogrammes consisted of 3 sessions per week for 8 months. Each vibratory =ession included 6 bouts of 1 min (12.6 Hz in frequency and 3 cm in =mplitude with 60' of knee flexion) with 1 min rest between bouts. =ach walking session was 55 minutes of walking and 5 minutes of =tretching. Hip and lumbar BMD (g•cm-2) were measured using =ual-energy X-ray absorptiometry and balance was assessed by the blind =lamingo test. ANOVA for repeated measurements was adjusted by baseline =ata, weight and age. Results After 8 months, BMD at the femoral neck in the WBV group was =ncreased by 4.3% (P = 0.011) compared to the =alking group. In contrast, the BMD at the lumbar spine was unaltered in =oth groups. Balance was improved in the WBV group (29%) but not in the =alking group. Conclusion The 8-month course of vibratory exercise using a =eciprocating plate is feasible and is more effective than walking to =mprove two major determinants of bone fractures: hip BMD and =alance. Go to: Background Bone fracture is among the =ommonest and most expensive health problems in the population, =articularly in postmenopausal women [1]. The =ajor determinants of bone fractures are falls, bone fragility, loss of =alance and decrease of lower limb strength[2,3J. =hysical exercise is considered as an effective strategy, frequently =ecommended in general practice, for the prevention and management of =ostmenopausal osteoporosis[4,5]. =erobics, weight bearing and resistance exercises were all effective =ncreasing bone mass density[6]. =owever, arduous bone stress induced by vigorous weight-bearing =ctivities can increase the risk of injuries, particularly in the =Iderly[7]. =herefore, alternative strategies with a lower risk of injury have been =ought and usually included in the medical advice, such as walking 2 EFTA_R1_01261996 EFTA02330379 =rogrammes(81. =alking and moderate-intensity aerobic exercise programmes have been shown to reduce bone loss although they did not increase significantly =one mineral density (BMD) compared to controls in the first few years =f menopause[4] and =hey showed limited effects on bone in postmenopausal women[9]. Vibration could be a viable alternative in frail people(10,111. =hole-body vibration (WBV) is a new type of exercise that has been =ncreasingly tested for the ability to prevent bone fractures and =steoporosis[3,12-15J. =ecent studies of WBV have shown a positive effect of controlled WBV on =ait, body balance and motor capacity[16]. =owever, the treatment has to follow specific safety guidelines[17] to =revent exercise-related injuries (back pain, muscular discomfort, =tc.), such as limiting the exposure to vibration to a maximum of 10 =inutes and maintaining the posture of the participant in a semi-squat =tance with knees flexed, with active involvement of the leg muscles to =educe the transmission of vibration to the head. The currently marketed =evices that deliver sinusoidal vibration to the whole body use two =ifferent types of vibrating plates[171: a) =he whole plate oscillates up and down; b) reciprocating vertical =isplacements on the left and right side of a fulcrum, increasing the =ateral accelerations. A few studies have shown recently that there is =carce evidence of the effectiveness of the up-and-down plate for =ncreasing BMD in experimental animals[13j or =umans(15J; but =he literature is largely lacking studies of the effect of the =eciprocating plate technique. Currently available WBV exercise devices deliver vibrations =t frequencies of 15-60 Hz. Investigators usually administered =requencies at 15-35 Hz to obtain the maximum transmissibility =f the mechanical stimulus produced by the vibrating plate[18J. On =he other hand, since the resonance frequency for the WBV is in the =ange of 5-10 Hz [191, the =requencies lower than 20 Hz has been usually avoided. However, some =ecent studies have included in their protocols frequencies at 10—=5 Hz to allow for gentle adaptation in frail populations (nursing home =esidents, elder, rehabilitation programs, etc.)116,201. But, =o our knowledge, none of them have reported the specific effect of =hese low frequencies on bone mass. This knowledge could specially =ontribute to make decisions on the WBV programs to frail people. =owever, prior to administer these WBV programs in frail people, these =rograms have to be tested in healthy population. The purpose of the current =tudy is to determine whether 8 months of WBV exercise at 12.6 Hz using = reciprocating plate is more effective than walking for improving BMD =nd balance in healthy postmenopausal women. Go to: Methods Subjects and study design Figure <=pan class="figpopup-sensitive-area" style="cursor: pointer; =ext-decoration: none; position: absolute; top: Opx; opacity: 0; color: =ransparent; background-color: transparent; left: =3em;">Figurell shows that 36 postmenopausal =omen recruited through advertisements in local newspapers volunteered =o participate in the study; however, only the 28 who completed the =rial are included in the analysis. Informed consent was obtained from =11 qualified volunteers. The inclusion criteria were: at least 5 years =rom the last menstruation; adequate nutritional status according to WHO =orms (as determined by questionnaire); non-smoker; consumption of no =ore than four alcoholic beverages per week; the ability to follow the =rotocol; free from disease or medication known to affect bone =etabolism or muscle strength. A questionnaire designed to gather =nformation about current and previous dietary factors, including intake =f calcium and vitamin D, was administered. At baseline, serum =steocalcin and urinary deoxypyridinoline crosslinks and creatinine were =etermined as markers of bone formation and resorption, respectively[211. Figure 1 Flow-chart of =articipants throughout trial. Exclusion criteria were: acute hernia; =hrombosis; any pharmacologic intervention for osteopenia within the =revious 6 months; any history of severe musculoskeletal problems; =ngaged in high-impact activity at least twice a week (any =eight-bearing activity or exercise more intense than brisk =alking). All =ubjects were assigned at random to one of the study groups. A total of =4 women trained for 8 months on a vibrating plate via reciprocation =the WBV group). The other 14 women participated in a walking activity =the Walking 3 EFTA_R1_01261997 EFTA02330380 group). The WBV programme consisted of 96 training sessions =ithin a period of 32 weeks. The frequency of training was three times a =eek, with at least 1 day of rest between sessions in both experimental =roups. This study =as approved by the University's Bioethics Committee according to the =elsinki declaration. The WBV =roup The subjects =n the WBV group performed the vibration exercise in a standing =osition. In each session, vibration was provided by a commercially =vailable device (Galileo 2000, Novotec GmbH, Pforzheim, Germany). The =ubjects stood with feet side-by-side on the board, which produced =ateral oscillations of the whole body. During the vibration training =essions, the subjects were barefoot to eliminate any damping of the =ibration caused by footwear. The angle of flexion of the knees during =he vibration exercise was set at 60*. The tridimensional =cceleration was monitored by a triaxial accelerometer (TSD109F, =riaxial accelerometer 5G, Biopac Systems, USA) attached to the skin at =he level of the lumbar spine (L3) and normalised by body weight =g). During the =irst 2 weeks of training, the WBV group performed three sets of 1 =inute vibration with a frequency of 12.6 Hz of vibration stimulus, =eparated by 1 minute resting periods. The training load was increased =ystematically during the following 6 weeks, increasing by one set each =eek until the 6 sets of WBV that we consider to be the load of this =ntervention. The resting period between sets was 1 minute. The vertical =mplitude of WBV was set at 3 mm. The duration of the WBV programme was =bout 30 minutes, which included 10 minutes warm-up consisting of S =inutes of bicycling at 50 W and 5 minutes of static stretching for the =uadriceps and triceps surae muscle. The =alking group The =alking group trained outdoors. Each 1-hour session of walking was =nterspaced with two periods of S minutes each that included stretching =xercises. Two research assistants, who were experienced physical =ducation graduates, supervised this group. BMD =ssessment At =aseline and at 8 months, BMD (g•cm-2) of the right proximal =emur (femoral neck, trochanter and Ward's triangle) and lumbar spine =ere assessed using dual-energy X-ray absorptiometry (DXA, Norland =xcell Plus; Norland Inc., Fort Atkinson, USA). Standard positioning was used with =nterior-posterior scanning of the right proximal femur and the lumbar =olumn. The same experienced technician performed all the scans. In our =aboratory, the day-to-day precision (Coefficient of Variation %) was =bout 1% at lumbar and femoral neck sites, and it was about 1.2% at the =est of femoral sites. Balance =ssessment Postural =alance was assessed with a blind flamingo test, in which the barefoot =ubject stood on one leg, while the other leg was flexed at knee level =nd held at the ankle by the hand of the same side of the body, and with =yes closed. The number of trials that the subject needed to complete 30 = of the static position (the chronometer was stopped whenever the =ubject did not comply with the protocol conditions) was measured. The =utcome was expressed as number of trials (= number of falls + 1). In =ur group, the test-retest intra-observer reliability coefficient of =his test calculated (Intra Class Coefficient = 0.83) can be =onsidered as acceptable for field testing in Spanish adults [22]. Statistical analysis Mean and standard deviation (SD) are given as descriptive =tatistics. Baseline characteristics were compared using =tudent's t-test for independent samples. The =ffects between groups were tested by ANOVA for repeated measurements, =djusted by body weight, age and baseline data. All analyses were =erformed with SPSS version 13.0 software. A result was considered =tatistically significant when the P value =as < 0.05 for primary outcomes (BMD) and < 0.01 for secondary =utcomes. 4 EFTA_R1_01261998 EFTA02330381 Go to: Results No difference in the =ompliance of programmes was detected, and 78% of participants completed =he exercise programmes. In the WBV group, the mean frequency of =ttendance was 2.7 (SD 0.7) times per week, and no vibration- related =ide-effect or any adverse reaction was observed. In the Walking group, =he mean attendance was 2.8(SD 0.8) days per week. The baseline characteristics =f both groups are given in Table Table1.1. The groups were matched by age and =eight, which are major determinant anthropometric variables on the =train in WBV training. However, the WBV group had a trend (p > .200) =f higher weight and BMI than the walking group. Table Table22 also shows some imbalances =etween the groups, so the changes were analysed by adjusting baseline =ata and age. After 8 months, the BMD at the femoral neck of the WBV =roup was increased 4.3% (P = 0.011) compared =o the Walking group. The comparison of the changes in BMD at other =ices on the hip showed a trend for the higher effectiveness of the =ibratory exercise, but the difference did not reach statistical =ignificance. In contrast, BMD at the lumbar spine was unaltered in both =roups. The WBV group showed improved balance (29%), while the Walking =roup did not. The WBV group reduced more the BMI than the Walking group =3%; P = 0.049). Table 1 Baseline =haracteristics of the sample Table 2 Comparative effects =f vibratory (N = 14) and walking-based exercise (N = 14) programs =n postmenopausal women. The lateral acceleration received by the WBV group at =he lumbar spine (L3) (median 3.3 g, SD 1.3; maximal 11.6 g, SD 6.5) was =reater (P < 0.001) than the vertical =cceleration (median: 0.7 g, SD 0.5; maximal 6.4, SD =.6). Go to: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693558/#> Discussion Summary of main findings The main finding of the study was that the =ibratory exercise on a reciprocating plate was more effective than =alking for improving balance and BMD at the femoral neck. The =daptation of bone to physical activity and mechanical loading is =rucial to the improvement and/or maintenance of bone mass and =trength[18,231. =ccording to conventional wisdom, the stimulus should be different from =hat usually occurs in daily living to stimulate an adaptation of the =one tissue[24). =owever, recent studies suggested that extremely low magnitude but =igh-frequency mechanical vibration can strongly influence bone =orphology[13,25I =ecause of the reverberation. Lodder et al. [26] =alculated that with increasing age, BMD in women decreases 0.005 =/cm2 per year at femoral neck (95% CI, 0.001 to =.006 decreases) and 0.006 g/cm2 per year at lumbar spine (95% CI, =.00 to 0.007 decreases) excluding the influence of corticosteroid use. =herefore, preventing bone loss is a clinically relevant effect. The =urrent study showed a significantly (P = =.011) and clinically relevant mean effect preventing bone loss at =emoral neck (0.02 g/cm2 increase) but the mean effect at lumbar spine =0.01 g/cm2 decrease) was not clinically relevant. More in =etail, seven participants in the vibratory group and three in the =alking group prevented bone mass density loss (no change or improvement =n BMD) at femoral neck. A similar trend of the number of preventions =as observed at the lumbar spine, but the mean of improvements were =ower. In a whole, walking program did not prevent bone loss. The other =ositive finding of the current vibrating training programme was the =igh frequency of attendance at sessions (90%) of the participants who =ompleted the programme. The profile of the sample (highly sedentary =ostmenopausal women) showing retention of the current programmes (78%) =s similar but slightly lower than that of previous community =roup-based strategies to promote exercise in the elderly population =80-90%)[27J. =owever, strategies to improve retention of the programme should be =ursued (musical environment, behavioural education, =tc.). 5 EFTA_R1_01261999 EFTA02330382 Comparison with the =iterature Bone mass density Although moderate-intensity aerobic exercise =nterventions usually documented positive, but not statistically =ignificant, increases in bone mass[28]; =erschueren et al. 1151 =eported positive effects on hip BMD but not in total body or lumbar =pine BMD after 6 months of WBV using an up-and-down plate, lower =mplitudes (1.7-2.5 mm) and higher frequencies (35-40 =z) than the current study. However, these results reflected a similar =rend of adaptation to the current study. Russo et al[20] did =ot find any improvement in bone characteristics after 6 months of WBV =raining with a reciprocating plate with two sessions per week. =herefore, the number of sessions per week seems to play an important role to obtain the desired effect. Torvinen et al[3] =eported no effect on bones of healthy young adults after 8 months of =ertical WBV with 3-5 sessions per week using a lower amplitude =2 mm), different frequencies (15-45 Hz) and a multidirectional =ibration exposure of the body by variation of body position on the =late. The variability of the program contributed to make standing on =he platform less monotonous, but distributed the mechanical strains in =ifferent body sites. Therefore, the lack of effects on bone in the =tudy reported by Torvinen et al[3] could =e explained partially because the study used lower vertical amplitudes =han the current study, which are associated to a less mechanical =mpact, and the number of mechanical strains were shared by more =natomical sites. In addition, the sample population was younger than =hat of the current study. On the other hand, the non-significance at the lumbar level =an be attributed to the partial knee flexion during the vibratory =xercise reducing the effects of the mechanical impact [3]. =evertheless, Rubin et al[18] found =reater strain in the vertical axis than in the lateral axis using =ifferent devices based on platforms oscillating the plate up-and- down. =n contrast, the current study had higher lateral than vertical =cceleration by using a reciprocating plate that oscillated on a central =xis so that, when half of the platform is up the other half is down, =ausing a continuous balance of hips. Yamazaki et al[8] =emonstrated that moderate or walking exercise in postmenopausal women =ith osteopenia/osteoporosis maintained lumbar BMD via a suppression of =one turnover. Several studies showed that the effect of exercise on =umbar BMD in postmenopausal women seems to be quite modest (exercise =gt; 1% versus control < 1%)129] or =ven non-existent[30], and =he walking program of the current study did not induce any effect, =hich could be attributed, in part, to the better health status of the =ubjects of the current study (no case of =steopenia/osteoporosis). Balance Six-week WBV programs with =he use of a reciprocating plate at 3 sessions per week could reduce the =eclining balance in the elderly using 4-6 sets of 30-60 = at 35-40 Hz[10] or 4 =ets of 60 s at 10-26 Hz [16]. The =urrent 8-month trial showed that a vibrating exercise with a =eciprocating plate could improve balance in postmenopausal women. In =ontrast, studies of 8 months using an up-and-down plate did not show =ny improvement of balance[3]. This =ifference between devices could be explained, in part, because: a) the =alance and the strength of lower limbs declines with age, particularly =n the lateral direction[31], the =irection in which the reciprocating plate used in the current study =howed the greater mechanical acceleration; b) the studies differed in =he methodology of balance assessment. Therefore, further research is =equired to determine the adequate dose-response of vibration training =eeded to improve balance. Body mass =ndex The current =tudy reported a positive effect of WBV at 12.6 Hz on BMI compared to =alking group. This amelioration could be partly attributable to the =rend of the higher BMI of WBV group at baseline. Other previous study =id not find this positive effect (p < .05) on weight loss using WBV =t higher frequencies (25-45 Hz) compared to a control group =lthough they also found a trend of weight loss[3]. Other =uthors also reported that vibratory training at 35-40 Hz was =ore effective to reduce fat mass than resistance training [15]. In =ontrast, another WBV at 35-40 Hz 6 EFTA_R1_01262000 EFTA02330383 program in untrained young =emales did not show a change in weight and authors reported a small but =ignificant increase of fat free mass[321. On =he whole, further research combining the analysis of the changes of fat =ree mass and lean mass is needed to elucidate this controversy and the =echanisms of weight change. Limitations The main limitations of the current study are the sample =ize, the characteristics of the sample and the type of device employed. =he size of sample could limit the chance of finding a significant =ffect on the BMD of the lumbar spine, but the mean of change (-0.01 =r/cm2) and the mean effect compared to walking group (0%) =acked of clinical relevance. In addition, this lack of effect is =onsistent with previous studies115]. =hanger of BMD at the trochanter and Ward's triangle were close to reach =tatistical significance, possibly due to the small sample size because =he statistical power was 30%. In addition, the observed mean effect =3-5%) was greater than the reliability of the measurements =1.2%). Therefore, we could consider that the WBV was more effective to =revent the bone mass density loss at hip area (femoral neck, Ward's Triangle and trochanter) than the walking programme. The generalisation of results =as to be largely confined to healthy postmenopausal women, because we =ecruited this type of population to reduce the influence of some =otentially contaminant variables (hormone replacement therapy, =etabolic disorders, malnutrition etc.)1211. =ubin et al. 125] and =orvinen et al. 131 =peculated that a population with osteopenia or osteoporosis could =btain greater increases of BMD due to low baseline scores. In this =ense, the Walking group showed a trend of lowers BMI, BMD and balance =t baseline because the randomisation procedure applied to sample was =ot blocked by means of these variables. The imbalance of BMD could =ifficult to find more positive effects of the WBV group compared to the =alking group, but the imbalance of BMI could benefit to find =omparative ameliorations in WBV. On the other hand, the results obtained has to be =estricted to devices designed to produce reciprocating vertical =isplacements on the left and right side of a fulcrum, which increases =he lateral accelerations. Nevertheless, this type of device is one of =he most frequently chosen for clinical use and for sport training. In =ddition, because the vertical strain was lower than the lateral strain, =he effects of vibratory training on the lumbar spine could require a =onger period of training or extra loading (e.g. a back-pack with =eights, a higher amplitude of vibration or less knee flexion to reduce =he attenuation of vibration throughout the body). Implications and future research Professionals could expect =reater reductions of bone fracture risk by prescribing WBV exercise =ather than a walking program alone. Therefore, a vibration loading with =ow amplitude (3 mm) and medium intensity (12.6 Hz), could be used to =revent age-related bone loss at the hip, specially in frail =opulations. However, knowledge of the optimal dosage of vibratory =xercise requires further research. In addition, the effects of =ifferent doses of vibratory exercise and the effects of a mixed =ibratory and walking exercise are unknown. Go to: Conclusion The 8-month vibratory =xercise is feasible and more effective than walking to improve two =ajor determinants of bone fractures: hip BMD and =alance. Go to: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693558/1O Competing =nterests The =uthor(s) declare that they have no competing interests. Go to: Authors' =ontributions 7 EFTA_R1_01262001 EFTA02330384 NG was =nvolved in the conception, planning and designing this study, the =cquisition of data, analysis and interpretation of data, and writing =he manuscript. AR was involved in the planning and organising this =esearch, the acquisition of data, analysis and interpretation of data, =nd drafting the manuscript. AL was involved in the acquisition of data =nd assisting in the writing of manuscript. All authors read and =pproved the final manuscript. Go to: Pre-publication =istory The =re-publication history for this paper can be accessed here: http://www.biomedcentral.com/1471-2474/7/92/prepub Go to: chttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693558/#> Acknowledgements This research was supported =y the Health Department of the Government of Extremadura (Socio =anitary Research SCSS0466) in Spain and the Portuguese Fundation =uganio d'Almeida. Go to: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693558/#> References * Roudsari BS, Ebel BE, Corso PS, Molinari NA, Koepsell =D. The acute medical care costs of fall-related injuries among the U.S. =lder adults. Injury. 2005;36:1316-1322. doi: =0.1016/j.injury.2005.05.024. [PubMed) [Cross Ref] * Kannus P. Parkkari J. =iemi S Age-adjusted incidence of hip fractures. Lancet. 1995;346:50-51. doi: =0.1016/50140-6736(95)92679-8. [PubMed] [Cross RefJ • Torvinen S. Kannus P. =ievanen H. Jarvinen T. Pasanen M. Kontulainen S. Nenonen A. =arvinen T. Paakkala T. Jarvinen M. Oja P. Vuori I Effect of =-month vertical whole body vibration on bone, muscle performance, and =ody balance: a randomize controlled study. J Bone Miner Res. 2003;18:876-884. doi: =0.1359/jbmr.2003.18.5.876. [PubMed] [Cross Ref] * Shea B, Bonaiuti D, lovine =, Negrini 5, Robinson V, Kemper HC, Wells G, Tugwell P, Cranney A. =ochrane Review on exercise for preventing and treating osteoporosis in =ostmenopausal women. Eura =edicophys. 2004;40:199- 209.[PubMed] • Wallace L, Boxall M, Riddick N. =nfluencing exercise and diet to prevent osteoporosis: lessons from =hree studies. Br 1 Community =urs. 2004;9:102-109.[PubMedj • Bonaiuti D, Shea B, lovine R, =egrini 5, Robinson V, Kemper HC, Wells G, Tugwell P, Cranney A. =xercise for preventing and treating osteoporosis in postmenopausal =omen. Cochrane Database Syst =ev. 2002:CD000333. [PubMed] • Kallinen M. Markku A Aging, physical =ctivity and sports injuries. Sports =ed. 1995;20:41-52.&nbs=; [PubMed] • Yamazaki S. Ichimura S. Iwamoto J. =akeda T. Toyama Y Effect of walking exercise on bone metabolism in =ostmenopausal women with osteopenia/osteoporosis. J Bone Miner Metab. 2004;22:500-508. doi: =0.1007/s00774- 004.0514.2. [PubMed] [Cross Ref] * Palombaro KM. Effects of =alking-only interventions on bone mineral density at various skeletal =ites: a meta-analysis. J Geriatr Phys =her. 2005;28:102-107.<=pan class="ref nowrap pubmed" style="white-space: nowrap;">[PubMed] * Bautmans I, Van Hees E, Lemper JC, =ets T. The feasibility of Whole Body Vibration in institutionalised =lderly persons and its influence on muscle performance, balance and =obility: a randomised controlled trial 8 EFTA_R1_01262002 EFTA02330385 [ISRCTN62535013] BMC Geriatr. 2005;5:17. doi: 10.1186/1471.2318-5-17.[PMC free article] =span class="ref nowrap pubmed" style="white-space: nowrap;">[PubMed] [Cross Ref] ` Hass CT. Turbanski S. =essler K. Schmidtbleicher D The effects of random whole-body-vibration =n motor symptoms in Parkinson's disease. NeuroRehabilitation. 2006;21:29-36. [PubMed] • Flieger J. Karachalios Th. Khaldi L =aptou P. Lyritis G Mechanical stimulation in the form of vibration =revents postmenopausal bone loss in ovariectomized rats. Calcif Tissue Int. 1998; 63:510-514. doi: =0.1007/5002239900566. [PubMed][Cross Ref] • Rubin C. Turner S. Bain =. Mallinckrodt C. McLeod K Low mechanical signals strengthen long =ones. Nature. 2001;412:603-604. doi: =0.1038/35088122.[PubMed <http://www.ncbi.nlm.nih.gov/pubmed/11493908> ] [Cross Ref] ` Torvinen S. Kannus P. =ievanen H. Jarvinen T. Pasanen M. Kontulainen S. Jarvinen =. Jarvinen M. Oja P. Vuori I Effect of four-month vertical whole =ody vibration on performance and balance. Med Sc Sports Exerc. 2002;34:1523-1528. doi: =0.1097/00005768.200209000-00020. [PubMed] [Cross Ref] ` Verschueren S. Roelants Delecluse C. Swinnen S. Vanderschueren D. Boonen S Effect of 6-month =hole body vibration training on hip density, muscle strength, and =ostural control in postmenopausal women: a randomized controlled pilot =tudy.1 Bone Miner =es. 2004;19:352-359. =oi: 10.1359/MMR.0301245.[PubMed] [Cross Ref] • Bruyere 0. Wuidart M. =alma E. Gourlay M. Ethgen 0. Richy F. Reginster J Controlled whole body =ibration to decrease fall risk and improve health-related quality of =ife of nursing home residents. Arch =hys Med Rehabil. 2005;86:303-307. doi: =0.1016/j.apmr.2004.05.019. [PubMed] [Cross Ref] • Cardinale M. Rittweger J =ibration exercise makes your muscles and bones stronger: fact or =iction? 1 Br Menopause =oc. 2006;12:12-18. =oi: 10.1258/136218006775997261. [PubMed] [Cross Ref] • Rubin C. Pope M. Fritton =C. Magnusson M. Hansson T. McLeod K Transmissibility of 15-hertz to =5-hertz vibrations to the human hip and lumbar spine: determining the =hysiologic feasibility of delivering low-level anabolic mechanical =timuli to skeletal regions at greatest risk of fracture because of =steoporosis. Spine. 2003;28:2621-2627. doi: =0.1097/01.BRS.0000102682.61791.C9. [PubMed] [Cross Ref] ` Mester J. Kleinader =. Yue Z Vibration training: benefits and risks. Journal of Biomechanics. 2006;39:1056-1065. doi: =0.1016Thbiomech.2005.02.015.[PubMed] [Cross Ref] • Russo C. Lauretani F. =andinelli S. Bartali B. Cavazzini C. Guralnik J. Ferruci L =igh-frequency vibration training increases muscle power in =ostmenopausal women. Arch Phys Med =ehabil. 2003;84:1854-1=57. doi: 10.1016/S0003-9993(03)00357-5. [PubMed] [Cross Ref] • Delmas PD. Eastell R. =arnero P. Seibel M.I. Stepan J. Committe of Scientific Advisors of the =nternational Osteoporosis Foundation The use of biochemichal markers of =one turnover in osteoporosis. Committe of Scientific Advisors of the =nternational Osteoporosis Foundation. Osteoporos Int. 2000;11:52-17. doi: =0.1007/s001980070002. [PubMed] [Cross Ref] ` Rodriguez FA, Valenzuela =, Gusi N, Nacher S, Gallardo I. [Evaluation of the health-related =itness in adults (II): reliability, feasibility and reference norms by =eans of the AFISAL-INEFC] Apunts =ducacion Fisica y Deportes. 1998;54:54-65. Spanish.. • Eisman J Good, good, =ood... good vibrations: the best option for better =ones? Lancet. 2001;358:1924- 1925. doi: =0.1016/50140-6736(01)06975-6. [PubMed][Cross Ref] • Frost HM Skeletal =tructural adaptations to mechanical usage (STAMU): 1 Redefining Wolff's =aw: The bone modelling problem. Anat =ec. 1990;226:403-413. =oi: 10.1002/ar.1092260402. [PubMed] [Cross Ref] • Rubin C. Xu G. Judex S =he anabolic activity of bone tissue, suppressed by disuse, is =ormalized by brief exposure to extremely low-magnitude mechanical =timuli. Faseb =. 2001;15:2225-2229. =oi: 10.1096/fi.01-0166com. [PubMed] [Cross Ref] • Lodder MC. Lems WF. Ader Marthinsen AE. Coeverden SC. Lips P. Netelenbos JC. Dijkmans BA. =oos JC Reproducibility of bone mineral density measurement in daily =ractice. Ann Rheum =is. 2004;63:285-289. =oi: 10.1136/ard.2002.005678. [PMC free article] =span class="ref nowrap pubmed" style="white-space: nowrap;">[PubMed] [Cross Ref] ` King AC. Rejeski WJ. =uchner DM Physical activity interventions targeting older adults. A =ritical review and recommendations. Am = Prey Med. 1998;15:316—=33. doi: 10.1016/50749-3797(98)00085-3. [PubMed] [Cross Ref] 9 EFTA_R1_01262003 EFTA02330386 • Chubak J. Ulrich CM. =woroger SS. Sorensen B. Yasui Y. Irwin ML. Stanczyk FZ. Potter JD. =cTiernan A Effect of exercise on bone mineral density and lean mass in =ostmenopausal women. Med Sci Sports =xerc. 2006;38:1236-124=. doi: 10.1249/01.mss.0000227308.11278.d7. [PubMed] [Cross Ref] • Kelley GA. Kelley KS. =ran ZV Exercise and lumbar spine bone mineral density in postmenopausal =omen: a meta-analysis of individual patient data. J Gerontol A Biol Sci Med =ci. 2002;57:559-604.&n=sp; [PubMed <http://www.ncbi.nlm.nih.gov/pubmed/12196498> I • Wolff I. van Croonenborg J. Kemper Kostense P. Twisk J The effect of exercise training programs on bone =ass: a meta-analysis of published controlled trials in pre- and =ostmenopausal women. Osteoporos =nt. 1999;9:1- 12. =oi: 10.1007/s001980050109. [PubMed] [Cross Ref] Mille ML. Johnson ME. =artinez KM. Rogers MW Age-dependent differences in lateral balance =ecovery through protective stepping. Clin Biomech. 2005;20:607-616. doi: =0.1016/j.clinbiomech.2005.03.004. [PubMed] [Cross Ref] • Roelants M. Delecluse C. =oris M. Verschueren S Effects of 24 weeks of whole body vibration =raining on body composition and muscle strength in untrained =emales. Int J Sports =ed. 2004;25:1-5. =oi: 10.1055/s-2003-45238. [PubMed][Cross =efj Articles from BMC Musculoskeletal =isorders are provided here courtesy of BioMed Central Formats: Article PubReader ePub =beta) PDF =266K) Citation Share • Facebook * Twitter * Google+ Save =tems Add to FavoritesView more =ptions Similar articles in PubMed 10 EFTA_R1_01262004 EFTA02330387 • Effect of 6-month whole body vibration training on =ip density, muscle strength, and postural control in postmenopausal =omen: a randomized controlled pilot study.11 Bone Miner =es. 2004] • Effect of 12 months of whole-body vibration therapy =n bone density and structure in postmenopausal women: a randomized =rial.(Ann Intern Med. 2011) • [Effect of whole body vibration exercise on =steoporotic risk factors].[Dtsch Med Wochenschr. =009] • Exercise for health for early postmenopausal women: a =ystematic review of randomised controlled trials.[Sports Med. 2004] * Effectiveness and safety of vitamin Din relation to =one health.[Evid Rep Technol Assess (Full =..] See reviews...See =11... Cited by =ther articles in PMC • Effects of Whole-Body Vibration Therapy in Patients with =ibromyalgia: A Systematic Literature Review[Evidence-based Complementary a...] • Changes in Bone Biomarkers, BMC, and Insulin Resistance =ollowing a 10-Week Whole Body Vibration Exercise Program in Overweight =atino BoyslInternational Journal of Medic...] • Whole-body vibration exercise in postmenopausal =steoporosis[Przeglad Menopauzalny = =enop...] • Vibration stimuli and the differentiation of musculoskeletal =rogenitor cells: Review of results in vitro and in vivo[World Journal of Stem Cells. 2...] • Effects of Whole Body Vibration and Resistance Training on Bone =ineral Density and Anthropometry in Obese Postmenopausal Women[Journal of Osteoporosis. 2014] See all... Links • Cited in =ooks • Compound • PubMed • Recent Activity ClearTurn Off Low-frequency vibratory exercise reduces the risk of bone =racture more than wal... Low-frequency vibratory exercise reduces the =isk of bone fracture more than walking: a randomized controlled =rial BMC Musculoskeletal Disorders. 2006; =()92 High-frequency, low-intensity vibrations increase bone mass and =uscle strength ... High-frequency, low-intensity vibrations =ncrease bone mass and muscle strength in upper limbs, improving =utonomy in disabled children. J Bone Miner Res. 2011 =ug ;26(8):1759-66. doi: 10.1002/jbmr.402. PubMed The use of anaferon (pediatric formulation) for prophylaxis of =cute respiratory... The use of anaferon (pediatric formulation) =or prophylaxis of acute respiratory viral infections in preschool =hildren. Bull Exp Biol Med. 2009 Aug =148(2):266-9. 11 EFTA_R1_01262005 EFTA02330388 PubMed See =ore... • The feasibility of Whole Body Vibration in =nstitutionalised elderly persons and its influence on muscle =erformance, balance and mobility: a randomised controlled trial =ISRCTN62535013].[BMC Geriatr. 2005] • The effects of random whole-body-vibration on motor =ymptoms in Parkinson's disease.[NeuroRehabilitation. 2006] • Effect of 8-month vertical whole body vibration on =one, muscle performance, and body balance: a randomized controlled =tudy.(J Bone Miner Res. 2003] See more ... * Review Vibration exercise makes your muscles and =ones stronger: fact or fiction?[J Br Menopause =oc. 2006] • Anabolism. Low mechanical signals strengthen long =ones.[Nature. 2001) • Effect of 6-month whole body vibration training on =ip density, muscle strength, and postural control in postmenopausal =omen: a randomized controlled pilot study.[J Bone Miner Res. =004) • Transmissibility of 15-hertz to 35-hertz vibrations =o the human hip and lumbar spine: determining the physiologic =easibility of delivering low-level anabolic mechanical stimuli to =keletal regions at greatest risk of fracture because of =steoporosis.[Spine (Phila Pa 1976). =003] • Vibration training: benefits and risks.[) Biomech. 2006] • Controlled whole body vibration to decrease fall risk =nd improve health-related quality of life of nursing home =esidents.[Arch Phys Med Rehabil. =005] • High-frequency vibration training increases muscle =ower in postmenopausal women.[Arch Phys Med =ehabil. 2003] • Review The use of biochemical markers of bone =urnover in osteoporosis. Committee of Scientific Advisors of the =nternational Osteoporosis Foundation.[Osteoporos =nt. 2000] • Transmissibility of 15-hertz to 35-hertz vibrations =o the human hip and lumbar spine: determining the physiologic =easibility of delivering low-level anabolic mechanical stimuli to =keletal regions at greatest risk of fracture because of =steoporosis.[Spine (Phila Pa 1976). =003] • Review Good, good, good... good vibrations: the best =ption for better bones?[Lancet. =001] • Review Skeletal structural adaptations to mechanical =sage (SATMU): 1. Redefining Wolff's law: the bone modeling =roblem.[Anat Rec. 1990] • Anabolism. Low mechanical signals strengthen long =ones.[Nature. 2001] • The anabolic activity of bone tissue, suppressed by =isuse, is normalized by brief exposure to extremely low-magnitude =echanical stimuli.[FASEB J. 2001] • Reproducibility of bone mineral density measurement =n daily practice.[Ann Rheum Dis. 2004] • Review Physical activity interventions targeting =lder adults. A critical review and recommendations.[Am J Prey Med. =998] • Effect of exercise on bone mineral density and lean =ass in postmenopausal women.[Med Sci Sports =xerc. 2006] • Effect of 6-month whole body vibration training on =ip density, muscle strength, and postural control in postmenopausal =omen: a randomized controlled pilot study.[J Bone Miner Res. 2004] • High-frequency vibration training increases muscle =ower in postmenopausal women.[Arch Phys Med =ehabil. 2003] 12 EFTA_R1_01262006 EFTA02330389 • Effect of 8-month vertical whole body vibration on =one, muscle performance, and body balance: a randomized controlled =tudy.(1 Bone Miner Res. =003] • Effect of 8-month vertical whole body vibration on =one, muscle performance, and body balance: a randomized controlled =tudy.[J Bone Miner Res. 2003] • Transmissibility of 15-hertz to 35-hertz vibrations =o the human hip and lumbar spine: determining the physiologic =easibility of delivering low-level anabolic mechanical stimuli to =keletal regions at greatest risk of fracture because of =steoporosis.[Spine (Phila Pa 1976). =003) • Effect of walking exercise on bone metabolism in =ostmenopausal women with osteopenia/osteoporosis.[J Bone Miner Metab. 2004] • Exercise and lumbar spine bone mineral density in =ostmenopausal women: a meta-analysis of individual patient =ata.[J Gerontol A Biol Sci Med Sci. =002] * The effect of exercise training programs on bone =ass: a meta-analysis of published controlled trials in pre- and =ostmenopausal women.[Osteoporos Int. =999] • The feasibility of Whole Body Vibration in =nstitutionalised elderly persons and its influence on muscle =erformance, balance and mobility: a randomised controlled trial =ISRCTN62535013].[BMC Geriatr. 2005] Controlled whole body vibration to decrease fall risk =nd improve health-related quality of life of nursing home =esidents.[Arch Phys Med Rehabil. =005] • Effect of 8-month vertical whole body vibration on =one, muscle performance, and body balance: a randomized controlled =tudy.[J Bone Miner Res. 2003] • Age-dependent differences in lateral balance recovery =hrough protective stepping.[Clin Biomech =Bristol, Avon). 2005] • Effect of 8-month vertical whole body vibration on =one, muscle performance, and body balance: a randomized controlled =tudy.[J Bone Miner Res. 2003] • Effect of 6-month whole body vibration training on =ip density, muscle strength, and postural control in postmenopausal =omen: a randomized controlled pilot study.[) Bone Miner Res. 2004] • Effects of 24 weeks of whole body vibration training =n body composition and muscle strength in untrained females.[Int J Sports Med. =004] • Effect of 6-month whole body vibration training on =ip density, muscle strength, and postural control in postmenopausal =omen: a randomized controlled pilot study.[) Bone Miner Res. =004] • Review The use of biochemical markers of bone =urnover in osteoporosis. Committee of Scientific Advisors of the =nternational Osteoporosis Foundation.[Osteoporos =nt. 2000] • The anabolic activity of bone tissue, suppressed by =isuse, is normalized by brief exposure to extremely low-magnitude =echanical stimuli.[FASEB J. 2001] • Effect of 8-month vertical whole body vibration on =one, muscle performance, and body balance: a randomized controlled =tudy.[1 Bone Miner Res. =003] You are here: NCBI <http://www.ncbi.nlm.nih.gov/guide/» Literature > PubMed Central =PMC) Write to the Help Desk External =ink. Please review our privacy policy. NLM NIH DHHS USA.gov Copyright I Disclaimer I Privacy I Browsers I Accessibility I Contact National Center for Biotechnology =nformation, U.S. National Library of =edicine8600 Rockville Pike, Bethesda MD, 20894 USA 13 EFTA_R1_01262007 EFTA02330390 = 14 EFTA_R1_01262008 EFTA02330391