EFTA00304572.pdf

711 I JEFFREY EPSTEIN 6100 REO HOOK QUARTER B3 ST. THOMAS, USVI 00602-1348 DEUTSCHE BANK TRUST COMPANY AMERICAS NEW YORK, NEW YORK 10154 1-103-210 PAY TO THE ORDER OF Joseph Thakuria Two Thousand and 00/100' 44_""*"" n " 6/24/2014 $ t'2,000.00 ••••••••••••••••Orttlfrilnledrinfell* Joseph Thakuria 33 Dickinson Street, #2 Somerville, MA 02143 MEMO I I s I 8 n00071, /iii• 0:0210010334 OS let35266976e JEFFREY EPSTEIN 711 Joseph Thakuria DB JEE ckg 3526697 6/24/2014 JEFFREY EPSTEIN Joseph Thakuria 6/24/2014 2,000.00 2,000.00 711 2,000.00 DB JEE ckg 3526697 2,000.00 ;haulm ow n603-3224304 EFTA00304572 From: Jeffrey E. laevacahonh`gma; corn Subject: Re: Jeffrey -Please RESPOND ASAPI Date: June 24. 2014 al 1119 AM To: Lesley Droll licilard Kahn just send tide 2k tb joe today On Tue, Jun 24, 2014 at 11:51 AM, Lesley Groff wrote: below from Joe and invoice attached...Please let Rich know how much you wish him to send to Joe and or/Joe's dad... Begin forwarded message: From: Joseph Thakuria Subject: Re: Jeffrey -Please RESPOND ASAP! Date: June 24, 2014 11:33:15 AM EDT To: Lesley Groff Cc: Rich Kahn Hi Lesley and Rich, See attached invoice. I put this together based on my brief conversation with Jeffrey on Sat. The only payment that should go out ASAP is the exome sequencing work. That comes out to $1000 for the saliva sample I collected on Sat from him PLUS $1000 for exome sequencing of his fibroblasts PLUS $1000 for each person he wants to add to the study (if any). The whole genome sequencing through Illumina does not need to be paid until he gets the second consent form from me - about 2-3 weeks from now. But if he wants to send and just have me hold on to it, that's fine. This cost is $11,400 for rapid turnaround. If he wanted to include his parents for "trio analyses" that would be $21,000. All the other stuff is optional and explained in the attached invoice. Happy to discuss with him if there are any questions (specifically the EFTA00304573 On Tue, Jun 24, 2014 at 7:50 AM, Lesley Groff < > wrote: Morning Joe...Jeffrey wants Rich to send you your check as of yesterday! Rich needs you to please reply to the below email ASAP... this check must go out today to you. He will send Federal Express...Is the check to be made out to you personally? Or if not, to who? Please confirm check should be mailed to your home address...thanks, Lesley Begin forwarded message: From: Richard Kahn Subject: jeffrey epstein Date: June 23 2014 1:51:55 PM EDT To: Cc: Lesley Groff can you please confirm that check will be made payable to yourself and mailed to the following address below: Joe Thakuria 33 Dickinson St., #2 Somerville, MA 02143 jeffrey would like me to send today please advise if i should send via fed ex? thank you Richard Kahn HBRK Associates Inc. 575 Lexington Avenue 4th Floor New York NY 10022 tel fa npll EFTA00304574 From. Lesley Groff Subject: Re: Jeffrey -Please RESPOND ASAPI Oahe: June 24, 2014 al 12,04 PM To: Joseph Thalcuria Cc: Rich Kahn Thanks Joe...Rich will be sending you $2000 today via fed ex to your home address for now... thanks, Lesley On n 24 2 14 at 11:33 AM, Joseph Thakuria wrote: Hi Lesley and Rich, See attached invoice. I put this together based on my brief conversation with Jeffrey on Sat. The only payment that should go out ASAP is the exome sequencing work. That comes out to $1000 for the saliva sample I collected on Sat from him PLUS $1000 for exome sequencing of his fibroblasts PLUS $1000 for each person he wants to add to the study (if any). The whole genome sequencing through Illumina does not need to be paid until he gets the second consent form from me - about 2-3 weeks from now. But if he wants to send and just have me hold on to it, that's fine. This cost is $11,400 for rapid turnaround. If he wanted to include his parents for "trio analyses" that would be $21,000. All the other stuff is optional and explained in the attached invoice. Happy to discuss with him if there are any questions (specifically the large bioinformatics item / #7). I think if the check is in the $5000-6000 range just for the exomes, it can just get made out to me and sent to my home address. For larger checks including those other items, I wonder if it could be mailed to one of my family members. This is embarrassing but since I'm divorced and owe the ex some money, I don't want a large amount going into my personal account and potentially being at risk when it all needs to get used for this research. Anyway, let me know what Jeffrey is willing to EFTA00304575 From: Joseph Thakurla Subject: Re:Jeffrey •Please Date. June 24. 2 To: le:OOy Gf011111M. Cc: Rich Kahn Hi Lesley and Rich, See attached invoice. I put this together based on my brief conversation with Jeffrey on Sat. The only payment that should go out ASAP is the exome sequencing work. That comes out to $1000 for the saliva sample I collected on Sat from him PLUS $1000 for exome sequencing of his fibroblasts PLUS $1000 for each person he wants to add to the study (if any). The whole genome sequencing through Illumina does not need to be paid until he gets the second consent form from me - about 2-3 weeks from now. But if he wants to send and just have me hold on to it, that's fine. This cost is $11,400 for rapid turnaround. If he wanted to include his parents for "trio analyses" that would be $21,000. All the other stuff is optional and explained in the attached invoice. Happy to discuss with him if there are any questions (specifically the large bioinformatics item / #7). I think if the check is in the $5000-6000 range just for the exomes, it can just get made out to me and sent to my home address. For larger checks including those other items, I wonder if it could be mailed to one of my family members. This is embarrassing but since I'm divorced and owe the ex some money, I don't want a large amount going into my personal account and potentially being at risk when it all needs to get used for this research. Anyway, let me know what Jeffrey is willing to cover and if the check is large, I may ask that it go to my dad (who is absolutely trustworthy - he would just be hanging on to funds as we disburse it for the various research items). Thank you both of your help. Let me know if anything needs clarification. Joe Thakuria EFTA00304576 6/24/2014 J.E. Invoice: 1. Exome sequencing: This is $1000 each. Right now I only have JE's saliva sample for sequencing. If he wants to submit the kits I provided him with, it will be $1000 for each additional sample. = $1000 (+ $1000 for every additional exome for other people submitting saliva samples) 2. Exome sequencing of JE's fibroblasts: I discussed with JE the research significance of comparing his exome data on blood with his fibroblast cell lines (which I already have frozen down in liquid nitro at Boston Childrens Hospital). Sequencing this cell line would be an additional $1000. I'm going to try my best to get it in with this sequencing run but because they are cells, that may be tricky. (They'll get in the next round if they don't make this one.) = $1000 3. iPS cell lines: We've discussed making adult stem cells from JE's fibroblast cells. If we do this, he, like George Church, would be one of very few people in the world to have this done. With multiple cell passages, the process takes a minimum of 6 months and there's no guarantee it will work — but the failure rate is probably around l in 6 or less and eve in those instances, we can still do it — it would just take more time and some additional funds for reagents. Price = $10,000. This is pretty much at cost given the labor and reagents. I only know of I commercial group providing this service — and they charge more than $10,000/ induced pluripotent cell line. = $10,000 4. Whole genome sequencing through Illumina: I won't be able to send this on to Illumina until JE completes the second consent form which should be available in 1-2 weeks. If he wants to send it ahead of time though, I guess that's fine. = —$11,400 for rapid turnaround I don't know if JE's parents are living — but if he wanted to include them (which greatly aids my gcnome analysis to have that data to compare), the cost would be $21,000. See: hup://www.illumina.com/clinical/illumina_clinical_laboratory/igs_for_doctors/how_to_o rder.ilmn EFTA00304577 5. WholLgenome analyses: We only discussed very briefly so I'm not sure Jeffrey will remember but I mentioned to him that I was starting a medical genomics private practice that would charge for personal whole genome and exome analyses. We're planning to price this in the $10,000 range per patient and will include reanalysis of genomic data (based on our collective improved knowledge of genomic variants) on a yearly basis for 3 years. My plan for the first few people to sign up is to offer longterm biobanking of DNA and cells and lifelong reanalysis of data. Even if we expand as planned, because of the labor involved, we would only be able to offer this for our first few patients. Essentially, I would be the personal medical genomicist for these people. To my knowledge, no such service is available yet. If he's interested... = $10,000 6. Personalized longevity studies: Funding for genetics research in academia generally relies on federal NIH funding or pharma funding — which, respectively, are disease and drug focused. I'm seeking funding to systematically introduce mutations in cell culture that would be expected to increase longevity. If he goes with number 5 (lifelong analyses) and number 3 above (generation of iPS cell lines from his fibros), I would bundle this work into #5 and do the genomic engineering on his iPS cells when they're available. I would use a CRISPR/Cas9 platform to introduce the mutations. I would need the money for reagents but this work would essentially be included with #5 for JE since he would be one of the first. it's so labor intensive (the technology is brand new so there are no automated systems to do this yet). = free if going with #5 + CRISPR/Cas9 reagents(this should only be a few thousand) 7. Venus project: Jeffrey and briefly discussed a genomic research studying I'm dubbing the Venus project (he'll know what this). I can do this for him but doing this work would be greatly aided by having some good bioinformatic infrastructure. This infrastructure could be used for the Venus project, YPO analyses, and other projects. Total anticpated costs for this would be $160,00: Genomic hardware: $100,000 Genomic software: $60,000/yr (this is for 2 systems costing $30,000 each/yr) The software component would only need to be paid for 1 year because I'm confident I can get other funding to cover this once we publish data in the first year using these resources. = $160,000 This is a big ticket item (at least relative to my bank acct O) so I'm happy to discuss this item more with Jeffrey if he's interested in supporting this. If he covers this and pays for EFTA00304578 the exomes which $1000/person — and he mentioned 200 participants being in this project — I can deliver on this "Venus" research. So, if he goes with everything on this invoice, it's: I. $1000 ($1000 for every additional exomc on others he wants to include in the YPO study) 2. $1000 for exome sequencing of JE's fibros 3. $10,000 to create adult stem cells for JE from his fibro cell lines 4. $11,400 for his whole genome ($21,000 if he wanted to include both of his parents; not sure if this is even feasible) 5. $10,000 indefinite biobanking of his samples for eternity, lifelong reanalysis of genomic data on an annual basis, and CRISPR/Cas9 manipulation of his adult stem cells to introduce mutations in culture believed to increase longevity. I'm only offering this to Jeffrey. Because of all the labor involved, there's simply not enough bandwidth to offer this to more than a handful of people right now (at least in 2014). 6. Included in #5 7. $160,000 Bioinformatic infrastructure for the Venus project, the YPO study, and any other pet genomic projects Jeffrey might have interest in now or in the future. Total: $193,400.00 EFTA00304579 FedEx Ship Manage• - Print Your label's) 6/74/14, 1i] Fki From: Brie Klein 4B84 4380“2363. rt. 575 Leong'', Ave. 441 F1,304' hew Yrk. NY 10150 Ongn ID JRBA Fecuysz E • CM! Seep Dsas 24.1UN14 AAVJgt 0.5 LB CAD: :0031'.23=3490 SHIP TO: pm 750.989$ Joseph Thakuria 33 Dockinson Street, #2 SOMERVILLE, MA 02143 84.L SENDER Detvory Address Br Cod. [1 Ref@ twoice RO N Dept 11 II III TRI(._ 7704 0218 8364 I toot I WED - 25 JUN 10:30A PRIORITY OVERNIGHT RES 02143 EM DUTA Aner pnininp Mrs Isbal I Use the •6 late button on Ina page to prn your 40410 your loSel or oklet prtnter Paean se pone., poor along iho borironul hoe 3 Place bur n shrerng pouch KO "ono your Kinnear so nal the batoclo portion or the waei can be lead err scanned Warning use only die printed °trains, later to. stupor, 9 31310/00037 of Ins label ror shsprog prrposes s 03~4,1 and COW 13...110I 33(1,0303 Charges Moog asrli dov canc. .it von, [pa a Øt fluster UK of ilvs sysherncoisuules Yaw WC -10pr 10 he seerce carrons in re cunenl FeclEx Serra Grace, wart* on *den corn Feat ova not or responsible ror bry dam ,4 excess& $100 pet package. ~Ow the Ms" 01.400. amar. debY 000.0,101ri 1014• 10.7 0' mivnlorrnalion weer rou rare s Niger rare man acroonse charge docuraere your &curler and 'de a Omhy cairn I. smilatess lound n the current a AJEA Semite Guide apply Your napn lo recover WPM :a3E. x lat prir Ices. mica ma mimic ewe o4 Art package. rose of sales roam newer prat scompys lees. cops and other bres (303.magtratttle, 331.031. 3333kfila consequenlial. or swim fl ied lo ne Teaser or $100 or the Pullin-Reel (*darnel value Recovery Cannot exceed actual documented Kss laili373311 ror teens of "n apery.," sup 4 $1 op° e g Awry pet", metals rrpo11a0Minstruments and 3433( 11331, Lunn rn our Sersternenote Yitaitn dare Oe Med wean strict eine ens 4. see axe« edtx SMw,a Gyre IAA US BOS hups://www.fedex.com/sIOPPlogishipmeniConfirmationAction.hanclle7methodedoContinue Page 1 of 1 EFTA00304580